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ORTHOVISC ® High Molecular Weight Hyaluronan

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If you have tried pain relievers and they are not giving you enough relief, know that there is more you can do to help manage your knee pain and restore movement. ORTHOVISC is an FDA-approved, non-drug therapy made from ultra-pure natural hyaluronan. It restores the natural joint fluid (hyaluronan) that cushions, protects, and lubricates your knee joint. With better cushioning, your knee can move and function better. ORTHOVISC contains the highest amount of hyaluronan available in a multi injection series per injection and is free of any additives1



Frequently Asked Questions 

Is ORTHOVISC right for me? 
If knee pain is keeping you from doing what you love and you’ve tried other treatments (otc and prescription pain relievers, exercise, physical therapy, corticosteroid injections) and nothing seems to work or is no longer effective, ORTHOVISC may be right for you. only your doctor can determine what treatment may be best for you.

How quickly can I expect pain relief and how long will it last? 
With just 3-4 consecutive, weekly injections, ORTHOVISC can provide up to 6 months of knee pain relief.1 Everyone responds differently, but some people experience pain relief after the first injection.

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Patient Stories

Cynthia's Story

Cynthia loves to run and stay active with her two small children. After many years of discomfort and pain with her knee OA, and unsuccessful physical therapy, Cynthia turned to her doctor for guidance. In Cynthia’s words, “ORTHOVISC® High Molecular Weight Hyaluronan helped redefine my life.” Watch for more of her story.


Debbie's Story

Debbie is a longtime nanny and caregiver. After trying almost everything for her knee pain, Debbie didn’t know where to turn. She and her doctor decided to try ORTHOVISC® High Molecular Weight Hyaluronan for her knee OA. Find out how Debbie was able to get to her passion for helping others.


Lois's Story

Lois has been a ballet dancer for many years. Her osteoarthritis in her knees slowly began to interfere with her passion. With multiple series of ORTHOVISC® High Molecular Weight Hyaluronan treatments, watch how Lois was able to get back to her passion of dance.


What To Expect

See a patient receive an ORTHOVISC® High Molecular Weight Hyaluronan injection.


Technical Overview

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ORTHOVISC is a non–avian sourced viscosupplementation with lasting efficacy for up to 6 months. ORTHOVISC is derived from bacterial cells. ORTHOVISC is given as an injection into your knee joint (administered by a health professional) once a week for 3-4 consecutive weeks. After 3-4 injections, studies have shown pain relief that lasts for up to 6 months.1 Although individual results vary, some people feel relief after the first injection. Talk to your doctor and determine the number of ORTHOVISC injections that is right for you.



Important Saftey Information

ORTHOVISC is indicated in the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and to simple analgesics, e.g., acetaminophen. in clinical studies, the most commonly reported adverse events were arthralgia, back pain, and headache. Other side effects included local injection site adverse events.


ORTHOVISC is contraindicated in patients with known hypersensitivity to hyaluronate formulations or known hypersensitivity (allergy) to gram positive bacterial proteins. ORTHOVISC should not be injected in patients with infections or skin diseases in the area of the injection site or joint. strict aseptic technique should be used. The effectiveness of more than one course has not been established.  


ORTHOVISC® is a registered trademark of Anika Therapeutics, Inc. Marketed and Distributed by DePuy Mitek, Inc

1.ORTHOVISC manufacturers full prescribing information