chronOS® Bone Graft Substitute (BGS) is a synthetic β-tricalcium phosphate bone void filler which is radiopaque, resorbable and osteoconductive.
chronOS Strip is indicated for:
chronOS Strip, combined with autogenous blood and/or bone marrow or autograft is intended to be used in the spine for posterolateral fusion. Following placement into the bony void, chronOS Strip resorbs and is replaced with bone during the healing process.
chronOS Preforms and Granules are indicated for:
|Osteoconductive||Provides a scaffold for bony ingrowth|
|Available as granules, preformed shapes, and strips||Multiple formulations designed to meet surgeon's needs|
|Can be perfused with the patient’s own blood or bone marrow||Potential to increase biological activity at the defect site|
|100% synthetic||Reduced risk of disease transmission|
|Potential to reduce operation time and morbidity associated with iliac crest harvests||Less pain to patient
Guaranteed sufficient quantity of bone graft substitute
Potentially shortens OR time
|Standardized pore sizes||Designed for optimal environment for vascularization and bony infiltration|
|Resorbs in 6-18 months 1, 2||Resorption rate is similar to the regeneration of new bone
Replaced with bone in a timely manner
1. PS Eggli, W Muller, RK Schenk. "Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits—a comparative histomorphometric and histologic study of bony ingrowth and implant substitution." Clinical Orthopaedics and Related Research, 232: 127 - 138. 1988.
2. D Buser, B Hoffmann, JP Bernard, A Lussi, D Mettler, RK Schenk. "Evaluation of filling materials in membrane protected bone defects—a comparative histomorphometric study in the mandible of miniature pigs." Clin Oral Implants Res, 9: 137 - 150. 1998.
All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.