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About this product

Division: Spine
Category: Lumbar Degenerative

The SYNFIX® LR System is a comprehensive set of implants and instruments designed for stand-alone anterior stabilization of the lumbar spine from L2 to S1.

The SYNFIX LR System is a standalone ALIF device that incorporates the benefits of an anterior plate and a radiolucent interbody spacer. The design creates a zero-profile construct and includes four locking screws that provide anterior fixation and stability.

SYNFIX LR System DePuy Synthes Companies

Indications for Use



The SYNFIX LR System is a standalone anterior interbody fusion device indicated for use in patients with degenerative disc disease (DDD) at one or two contiguous levels from L2 to S1. These DDD patients may also have up to Grade 1 spondylolisthesis at the involved level(s). The interior of the spacer component of the SYNFIX LR System can be packed with autograft.


DDD is defined as back pain of discogenic origin with degeneration of the disc confirmed by history and radiographic studies. These patients should be skeletally mature and have had six months of nonoperative treatment.




Use of the SYNFIX LR System is contraindicated when:


  • There is active systemic infection, infection localized to the site of the proposed implantation, or when the patient has demonstrated allergy or foreign body sensitivity to any of the implant materials (PEEK, titanium, aluminum and/or niobium)
  • Severe osteoporosis may prevent adequate fixation and thus preclude the use of this or any other orthopaedic implant
  • Where patient anatomy or pathology prevents insertion of all four locking head screws


Features & Benefits

  Features Benefits
SYNFIX LR System rendering | DePuy Synthes Companies
SYNFIX LR System profile | DePuy Synthes Companies
Stand-alone ALIF implant

Biomechanically equivalent to a spacer with pedicle screws1


PEEK spacer provides modulous of elasticity similar to cortical bone


Titanium plate with locking screws with 15 and 30mm lengths provide stable fixation

Zero-profile construct

Spacer and plate fit completely within the disc space
Anatomic shape

The SYNFIX-LR is convex to match the anatomy of the disc space


Two footprints, two lordotic angles, and five heights are offered to accommodate individual patient anatomy

Screw and plate fixation

One-step conical locking mechanism eliminates need for blocking plate


Locking screws provide stability and load transfer near the cortex of the vertebral body


Four locking screws diverge to form a fixed-angle construct that creates a wedge of bone for fixation


Self-tapping cortical threads allow largest possible core diameter for maximum fixation

1C.M. Cain, P. Schleicher, R. Gerlach, R. Pflugmacher, F. Schotz M, F. Kandziora “A New Stand-Alone Anterior Lumbar Interbody Fusion Device Biomechanical Comparison with Established Fixation Techniques.” Spine. 2005 Dec 1; 30 (23)” 2631-6.


All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.
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