ORTHOVISC® High Molecular Weight Hyaluronan

Division: Sports Medicine
Category: Early Intervention

ORTHOVISC® High Molecular Weight Hyaluronan is a FDA approved treatment made from ultra-pure hyaluronan, a naturally occurring lubricant found in healthy knee joints. ORTHOVISC® Hyaluronan is a NON-AVIAN sourced viscosupplement with lasting efficacy for up to 6 months.

As OA of the knee progresses, prescription medications such as NSAIDs, COX-2 Inhibitors and intraarticular corticosteroid injections may be appropriate next course of therapy choices. Due to contraindications, co-morbidities or adverse events, COX-2 Inhibitors and/or NSAIDs may or may not be an appropriate choice.

These treatments may have provided relief to date but may no longer seem effective due to the disease state progression. A next-step consideration in the Continuum of Care for Knee Osteoarthritis is Hyaluronic Acid Injections, such as ORTHOVISC® Hyaluronan.

Indications for Use

ORTHOVISC® Hyaluronan is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics, e.g. acetaminophen. ORTHOVISC® Hyaluronan may enhance the viscoelastic properties of synovial fluid to relieve pain and increase mobility.

Features & Benefits

ORTHOVISC® Hyaluronan is a NON-AVIAN sourced hyaluronic acid injection therapy which has up to six months of clinically proven efficacy with 3 or 4 injections.1. Patients with known avian allergies may be prescribed ORTHOVISC® Hyaluronan. ORTHOVISC® Hyaluronan is made from ultra-pure natural hyaluronan, and has no buffers or preservatives. It may restore the molecular weight, elasticity and viscosity of the osteoarthritic knee to more closely resemble the synovial fluid of a healthy knee. ORTHOVISC® Hyaluronan contains the highest concentration of hyaluronan per injection than all other viscosupplements in the United States.

1. ORTHOVISC® High Molecular Weight Hyaluronan manufacturer’s full prescribing information


All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.