chronOS® Bone Graft Substitute

Division: CMF
Category: Biomaterials

chronOS® bone graft substitute (BGS) is a synthetic β-tricalcium phosphate bone void filler which is radiopaque, resorbable and osteoconductive.

Indications for Use


  • Intended to fill, augment or reconstruct periodontal or bony defects of the oral and maxillofacial region. Specifically, for the augmentation of deficient maxillary and mandibular alveolar ridges and the treatment of oral, maxillofacial and dental intraosseous defects including: ridge augmentation; sinus lifts; craniofacial augmentation; filling of defects of endodontic origin; filling of cystic defects; filling of extraction sites; filling of lesions of periodontal origin; repair of traumatic defects of the alveolar ridge; filling resection defects in bone tumors, cysts or other osseous defects; and substitute for autogenous or allogenic bone grafts.
  • Intended to be gently packed or placed into the site and may be combined with autogenous blood or bone marrow, or saline.


  • Intended for the repair or filling of craniofacial defects and craniotomy cuts with a surface area no larger than 25 cm2.
  • Indicated for the restoration or augmentation of bony contours of the craniofacial skeleton, including fronto-orbital, malar and mental areas.
  • Intended to be gently packed or placed into the site.

chronOS resorbs and is replaced with bone during the healing process.


Features & Benefits

chronOS® Bone Graft Substitute contains calcium and phosphorus, two of the main mineral constituents of bone. During the healing process, it is resorbed and replaced by bone between 6 – 18 months.

chronOS® Bone Graft Substitute

  • Available as granules and preformed shapes
  • Provides the ideal pore size (100 – 500 µm) and porosity (60 – 70%) for bony ingrowth
  • Can be perfused with the patient’s own blood or bone marrow
  • Can be used alone or mixed with autograft for large volume defects
  • Fully synthetic – no risk of disease transmission
  • Reduces operation time and morbidity associated with iliac crest harvests, which may lead to a shorter hospital stay and therapy




chronOS® Bone Void Filler Brochure




All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.