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About this product

Division: Biomaterials
Category: Spine

chronOS® Bone Graft Substitute (BGS) is a synthetic β-tricalcium phosphate bone void filler which is radiopaque, resorbable and osteoconductive.

chronOS Bone Graft Substitute bone void filler in various shapes chronOS Bone Graft Substitute rendering chronOS Bone Graft Substitute rendering chronOS Bone Graft Substitute granules in different sizes chronOS Bone Graft Substitute strips in various sizes
 

Indications for Use

chronOS Strip is indicated for:

 

  • Bony voids or gaps that are not intrinsic to the stability of the bony structure
  • Use in the treatment of bony defects created surgically or through traumatic injury

 

chronOS Strip, combined with autogenous blood and/or bone marrow or autograft is intended to be used in the spine for posterolateral fusion. Following placement into the bony void, chronOS Strip resorbs and is replaced with bone during the healing process.

 

chronOS Preforms and Granules are indicated for:

 

  • Bony voids or gaps that are not intrinsic to the stability of the bony structure
  • Use in the treatement of bony defects created surgically or through traumatic injury
  • chronOS is intended to be gently packed or placed into bony voids or gaps of the skeletal system (i.e., the extremities, spine, and pelvis) and may be combined with autogenous blood and/or bone marrow. Following placement into the bony void, the calcium phosphate resorbs and is replaced with bone during the healing process.

 

Features & Benefits

Features Benefits
Osteoconductive Provides a scaffold for bony ingrowth
Available as granules, preformed shapes, and strips Multiple formulations available to meet surgeon's needs
Can be perfused with the patient’s own blood or bone marrow Increases biological activity at the defect site
100% synthetic No risk of disease transmission
Reduces operation time and morbidity associated with iliac crest harvests Less pain to patient

 

Guaranteed sufficient quantity of bone graft substitute

 

Shortens OR time

Standardized pore sizes Optimal environment for vascularization and bony infiltration
Resorbs in 6-18 months 1, 2 Resorption rate is similar to the regeneration of new bone

 

Replaced with bone in a timely manner

 

1. PS Eggli, W Muller, RK Schenk. "Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits—a comparative histomorphometric and histologic study of bony ingrowth and implant substitution." Clinical Orthopaedics and Related Research, 232: 127 - 138. 1988. 

 

2. D Buser, B Hoffmann, JP Bernard, A Lussi, D Mettler, RK Schenk. "Evaluation of filling materials in membrane protected bone defects—a comparative histomorphometric study in the mandible of miniature pigs." Clin Oral Implants Res, 9: 137 - 150. 1998. 

DSUS/MOC/0416/0465 05/2016

All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.
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