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MONOVISC® High Molecular Weight Hyaluronan

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MONOVISC ® High Molecular Weight Hyaluronan

If you have tried over-the-counter (OTC) or prescription pain relievers and they are no longer providing the relief you need from pain associated with knee OA, know there is more that you can do to help manage your knee pain and restore your movement. MONOVISC is an FDA-approved, non-drug therapy made from ultra-pure, high molecular weight hyaluronan. It restores the natural joint fluid (hyaluronan) that cushions, protects and lubricates your knee joint. With better cushioning, your knee can move and function better. MONOVISC contains the highest concentration of hyaluronan available for a single injection.1



Frequently Asked Questions 

Is MONOVISC right for me?
If you’ve tried other treatments (OTC and prescription pain relievers, exercise, physical therapy, corticosteroid injections) and knee pain is keeping you from doing what you love, MONOVISC may be right for you. Only your doctor can determine what treatment may be best for you.

What are the benefits of MONOVISC?
Clinical trials conducted in the United States have shown that MONOVISC provides pain relief to patients.

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Technical Overview

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MONOVISC is a non–avian sourced viscosupplementation with lasting efficacy for up to 6 months.1 MONOVISC is derived from bacterial cells. MONOVISC is a single injection administered directly into your knee joint by a healthcare professional. After a single injection, studies have shown that pain relief lasts for up to 6 months. Although individual results may vary, some people feel relief immediately after their MONOVISC injection. Talk to your doctor to see if a MONOVISC injection is right for you.



Important Saftey Information

MONOVISC is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and to simple analgesics (e.g. acetaminophen). In clinical studies the most commonly reported adverse events were joint pain, injection site pain, joint swelling and joint effusion. Others included local injection site adverse events.


MONOVISC is contraindicated in patients with known hypersensitivity (allergy) to hyaluronan preparation or known hypersensitivity (allergy) to gram-positive bacterial proteins. MONOVISC should not be injected in patients with injections or skin diseases in the area of the injection site or joint or with known systemic bleeding disorders. Strict aseptic technique should be used.


MONOVISC® is a registered trademark of Anika Therapeutics, Inc. Marketed and Distributed by DePuy Mitek, Inc

1. MONOVISC manufacturers full prescribing information


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